Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length553 amino acids

Chemical FormulaC2721H4298N706O807S24

DescriptionStandard

        MAEHKMLPVPHTDTHAHTHTELKSAAHPRLFSDVRKFHFLVFQKAKAAVERSTAQTQNSRRTDIRSCLSFRDQSNMLPSVIAVLMLLSYTCGENPAIQVILTNKGLQYGKHTGTDWIQEILENVTLPDISGKFPIGRLGSVDYTLSGISITKVDLPEPSVEFYPNTTGLKSSMSGLSVALSGEWRTHYGIIHDGGTLDLALFSVSVMSIVELGKDANGHLSISSVTCTCTIGDVAIQFYGGASWIFRPFVPFFKGHIKGEIQSRICPKVEEVIVILEDHLQVMNVSFDVDQVLSLNLSLTGLPVIDASSLNLGLKGELYSIRTHKEPPFEAQSFTVPQQHSYMFSVGMSEFTLNSASYGCYSDGLLQATVNDSMIPPLSPVHLNTTSMGQFIPQLPKLFPGLLMSLTVYAREVPMFSLKPDAVKLDFQGTVKAFAILPNDTQAPLFTLNVDSNFSSKVWISGGRLEGSTEMENFTLTLIGSEVGTFQTDALENVVKMGIEMAVLPKVNVILGKGVDLPRMKSAQLVNSVLKVDEGFIVLCSDAEVLLTRNDFK
    

Molecular Weight60583.04 Da

Isoelectric Point (pI)5.82

Net Charge (pH 7.0)-10.11

Net Charge (pH 7.4) -11.35

Charge Density (pH 7.0) -0.0183

GRAVY Index0.09

Hydrophobic Moment 0.68

Boman Index0.14

Instability Index36.54

Aliphatic Index 96.53

Aromaticity 0.0796

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38765.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0290474 VERIFIED: NO

Provenance & Taxonomy

OrganismMastacembelus armatus [Animal]

FamilyBPI

Tax ID205130

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence