Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length471 amino acids

Chemical FormulaC2306H3720N590O674S19

DescriptionStandard

        VLVCYLYTTEHTPQISGHSSSGTASKCYFVLNAGRAIGIESLQQKLRTIQLKDVSGTEKLAIGKVEYSITGMQIVNLGLPKSALRLVAGTGVMLSVGDAYISLRGNWRVKYSWIIKASGSFELAVSELAISTTIAVKSDVTGRPTVSVTKCEATVGSVKVRFSGGASWLYNLFDSFINKALRNALQKQICPLVTASIAEMNKNLKTLNVLAKVDQYAELEYSMVESPVISNAMIDLGLKGEFYNIGQHKEPPFSPRPFLLPSQDTNMLYIGVSAFSINSAGFVYHRAGALCLYITNDMPCSVIQFKTQKTSQLDHIFQIGNMSPGLMMKLLVETVKEPIVTLEPNNMTVQASSKVTAYAIQPNSILSPLFVLKLEASVSAHIYVTGLKLAGHVTLNKIDMSLAESYVGPFQVTSLEDILTTVVKDVIIPKVNAGVKEGYPLPAIGKMQLVKSQLQVLKDYLLIGTDVTLTG
    

Molecular Weight51102.99 Da

Isoelectric Point (pI)8.96

Net Charge (pH 7.0)8.31

Net Charge (pH 7.4) 7.54

Charge Density (pH 7.0) 0.0176

GRAVY Index0.22

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index31.50

Aliphatic Index 106.75

Aromaticity 0.0743

Extinction Coeff. Reduced 43320.00

Extinction Coeff. Oxidized 43695.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0224420 VERIFIED: NO

Provenance & Taxonomy

OrganismSinocyclocheilus grahami (Dianchi golden-line fish) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria