Peptide Database

Peptide Namepeptide 4bb[K508A]

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard Statusnot Standard

Sequence Length20 amino acids

Chemical Formula-

Descriptioncontains X representing unresolved or non-standard residue

        EKIXQSLXFIXASDXLLHNV
    

Molecular Weight0.00 Da

Isoelectric Point (pI)0.00

Net Charge (pH 7.0)0.00

GRAVY Index0.00

Boman Index0.00

Instability Index0.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0103927 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configdouble-stapled cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermAcetylation

C-TermNone

Other ModsThe 'X' at position 4,8,11,15 indicates S-pentenylalanine, X(4) and X(8), X(11) and X(15) are cross-linked by hydrocarbon stapling; N-terminal acetylation

Bio-Activity Profile

Function

Antiviral Anti-RSV Fusion inhibition

TargetRespiratory syncytial virus (RSV); HEp-2 cells

Activity10.93±13.9 μM

MethodEC50 (RSV entry/spreading inhibition)