Peptide Database

Peptide NameSLAY-screened peptide P2597

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC90H126N22O27S

DescriptionStandard

        PLSSNGDCHLFIHYDYV
    

Molecular Weight1980.16 Da

Isoelectric Point (pI)5.05

Net Charge (pH 7.0)-1.88

Net Charge (pH 7.4) -2.05

Charge Density (pH 7.0) -0.1104

GRAVY Index-0.09

Hydrophobic Moment 0.11

Boman Index0.20

Instability Index78.11

Aliphatic Index 85.88

Aromaticity 0.1765

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 770.90

LogP -6.18

H-bond Donors 28.0

H-bond Acceptors 28.0

Rotatable Bonds 59.0

Heavy Atoms 140.0

Ring Count 6.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0077415 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/