Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length142 amino acids

Chemical FormulaC688H1080N172O205S6

DescriptionStandard

        MLPSVMAVFAILSCTSGETPAVQVTLTDKWLQYVKHVGAGWVQDMLEHITFPDISGDVDILIGHVDYTLSGIRITKCDLPEPVVEFYQQPTGLKTSIVGLSAALVGGWSTRFGLIHDGGSFDMAILSVSLTSVVQLGRDPEG
    

Molecular Weight15233.35 Da

Isoelectric Point (pI)4.63

Net Charge (pH 7.0)-8.15

Net Charge (pH 7.4) -8.63

Charge Density (pH 7.0) -0.0574

GRAVY Index0.37

Hydrophobic Moment 0.58

Boman Index0.25

Instability Index40.18

Aliphatic Index 106.27

Aromaticity 0.0775

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5900.78

LogP -52.41

H-bond Donors 205.0

H-bond Acceptors 207.0

Rotatable Bonds 490.0

Heavy Atoms 1071.0

Ring Count 25.0

Amide Bonds 147.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0372525 VERIFIED: NO

Provenance & Taxonomy

OrganismIconisemion striatum [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria