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MYP_133922
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Basic Information
Chol-PEG4-VG
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
42 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XGSGSGVALDPIDISIVLNKAKSDLEESKEWIRRSNGKLDSI
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0053655 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 1 indicates cholesterol-PEG4 conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
7e-07 μM
IC50
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0057861 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 1 indicates cholesterol-PEG4 conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.0001±0.0000001 μM
IC90
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0391632 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 1 indicates cholesterol-conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.00006±0.000035 μM
IC50
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0414648 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 1 indicates cholesterol-conjugated cysteine.
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.0017±0.00042 μM
IC90
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/