Peptide Database

Peptide NameSLAY-screened peptide P5232

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC77H125N27O30S2

DescriptionStandard

        MPRGNNHIGATTCEDQTQ
    

Molecular Weight1973.11 Da

Isoelectric Point (pI)5.30

Net Charge (pH 7.0)-1.42

Net Charge (pH 7.4) -1.70

Charge Density (pH 7.0) -0.0788

GRAVY Index-1.25

Hydrophobic Moment 0.38

Boman Index-0.22

Instability Index46.44

Aliphatic Index 27.22

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 947.46

LogP -14.85

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 64.0

Heavy Atoms 136.0

Ring Count 2.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0310594 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/