Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length470 amino acids

Chemical FormulaC2395H3717N587O697S11

DescriptionStandard

        MLTFWYFFLLLHLLIQQLDANPGLKVRITQKGLDYGKEIGLEILKQRIKEESFPDWSGREKSGVGDVDYTISGVRINTIEFPDASVSLIPGIGIKLSTQRAYATVSVNWNIRTWLFKDSGSGTVSISGVFITAVFTMSQDSTGHPSMSLDSCQMSIRGVEVKLNGTISWLYKFFTKYLEKPIQRSLDTHSCPNIRQGIQQIDAQLRTLQVPTQIDAFAQIDYSLVNSPGVFQSYIDLDLKGAIYPVGNWTDLAFVPAPFILPDKSDSMLYFGISEYFFKSASLAYYTAGAFNITIVEELSSYFNVTTETFGNIIPEIAEYYVEAQPAMLNLRAAAAPVVSLQTDTFTLEICASMEVLAVLPDSTTQSIFTVNIIANTSASLTIFEQKLIGSLCLNRFQLFLADSSVGFFEVSLLENFLSYVLRNGVIPAANAKLKNGFPLPNLDQIPLLRPVVKVNEGYLLISTDIDYKL
    

Molecular Weight52238.36 Da

Isoelectric Point (pI)4.92

Net Charge (pH 7.0)-11.23

Net Charge (pH 7.4) -11.77

Charge Density (pH 7.0) -0.0239

GRAVY Index0.19

Hydrophobic Moment 0.72

Boman Index0.18

Instability Index36.76

Aliphatic Index 104.13

Aromaticity 0.1149

Extinction Coeff. Reduced 61310.00

Extinction Coeff. Oxidized 61560.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067347 VERIFIED: NO

Provenance & Taxonomy

OrganismPlatysternon megacephalum [Bacterium]

FamilyBPI

Tax ID55544

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence