Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2307H3722N604O666S18

DescriptionStandard

        MKSWCLPLVALIAAAFSANPGVKIRLTQKGLEYGRQLGVASLLEKLKTAQIPDFSGKERVSPIGKVQYSLTNIHIVNLGLPQSSINLVPGSGVQLSISNAFINLRGNWRVKYLRIIKDSGSLDVNVNGLSISQTIAIKSDATGKPEASSAACSASVSSAKVKFHGGASWLYNLFSKFIDKALRKALEKQMCPLVAKSIADLNPRLKTLNVLAKVDKYAEIEYSMVSSPQISQPAIDLNLKGEFYNIGRHQEAPFPAPAFSLPAQSSNMIYIALSSFTPNSAGFVYNNAGVLSMYVTDDMIPRSSPIRLSTSTFGFFIPQIAQRFPNLMMKMLVKADKNPVVKFQPNVMTVDATATATAYAIQPNGTLSPLFVLNVDSSVSSQMSVSDLKLASRITLNKMSLSLGTSYVGDFKVNSLDNILQVILKLVVIPTVNVQLSKGYPLPALGKMKLVNTQLQIMQDYLMIGTDVQFTG
    

Molecular Weight51153.05 Da

Isoelectric Point (pI)9.69

Net Charge (pH 7.0)18.73

Net Charge (pH 7.4) 18.22

Charge Density (pH 7.0) 0.0397

GRAVY Index0.14

Hydrophobic Moment 0.85

Boman Index0.14

Instability Index38.95

Aliphatic Index 102.67

Aromaticity 0.0763

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0216064 VERIFIED: NO

Provenance & Taxonomy

OrganismOryzias sinensis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence