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MYP_133662
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Basic Information
EA-92
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Standard
92 amino acids
C405H628N116O161S
Standard
Sequence
EDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQA
Physicochemical Analysis
9730.07 Da
4.12
-16.03
-16.29
-0.1742
-1.45
0.40
-0.21
66.85
36.30
0.0217
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4453.45
-60.55
141.0
147.0
324.0
683.0
14.0
101.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0084279 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
EA
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
9:Phosphoserine; 61:Phosphotyrosine; 70:Phosphoserine; 85:Phosphoserine; 48:O-linked (GalNAc...) threonine; 50:O-linked (GalNAc...) threonine
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Antibacterial Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
Mammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour
PaperThe spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy PMID12442257 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12442257/
RECORD: Rec_0208305 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0266087 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Chromogranin/secretogranin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ser9 Phosphoserine; Tyr61 Phosphotyrosine; Ser70 Phosphoserine; Ser85 Phosphoserine
Bio-Activity Profile
Secretory granule peptide Neuropeptide precursor
Evidence URLhttps://www.uniprot.org/uniprotkb/CMGA_HUMAN/entry
RECORD: Rec_0363070 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
EA
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
9:Phosphoserine; 61:Phosphotyrosine; 70:Phosphoserine; 85:Phosphoserine; 48:O-linked (GalNAc...) threonine; 50:O-linked (GalNAc...) threonine
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Antibacterial Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
cells and noradrenergic neurons
Mammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for EA-92 (Homo sapiens): PMID 15326220,12442257 PMID15326220;12442257 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15326220/