Peptide Database

Peptide NameSLAY-screened peptide P1594

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC82H125N25O24S

DescriptionStandard

        ARFALHTCSHALAFASSS
    

Molecular Weight1877.09 Da

Isoelectric Point (pI)8.31

Net Charge (pH 7.0)0.96

Net Charge (pH 7.4) 0.66

Charge Density (pH 7.0) 0.0534

GRAVY Index0.55

Hydrophobic Moment 0.40

Boman Index0.21

Instability Index26.66

Aliphatic Index 71.11

Aromaticity 0.1111

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 778.43

LogP -10.21

H-bond Donors 30.0

H-bond Acceptors 28.0

Rotatable Bonds 57.0

Heavy Atoms 132.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0338544 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/