Peptide Database

Peptide NameProgonadoliberin-1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length72 amino acids

Chemical FormulaC356H545N101O107S4

DescriptionStandard

        QHWSYGLSPGGKRDLDNFSDTLGNMVEEFPRVEAPCSVFGCAEESPFAKMYRVKGLLASVAERENGHRTFKK
    

Molecular Weight8080.01 Da

Isoelectric Point (pI)6.92

Net Charge (pH 7.0)-0.07

Net Charge (pH 7.4) -0.43

Charge Density (pH 7.0) -0.0010

GRAVY Index-0.62

Hydrophobic Moment 0.70

Boman Index-0.09

Instability Index39.28

Aliphatic Index 54.17

Aromaticity 0.1111

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3354.67

LogP -34.95

H-bond Donors 118.0

H-bond Acceptors 113.0

Rotatable Bonds 266.0

Heavy Atoms 568.0

Ring Count 15.0

Amide Bonds 75.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0123769 VERIFIED: YES

Provenance & Taxonomy

OrganismHaplochromis burtoni [Animal]

FamilyProgonadoliberin

Tax ID8153

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods10:Glycine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Reproductive regulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour