Peptide Database

Peptide NameSLAY-screened peptide P2574

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H149N27O34S3

DescriptionStandard

        HCTSYQHNTPSMISNYYDIM
    

Molecular Weight2405.64 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-1.08

Net Charge (pH 7.4) -1.40

Charge Density (pH 7.0) -0.0539

GRAVY Index-0.72

Hydrophobic Moment 0.37

Boman Index0.02

Instability Index61.03

Aliphatic Index 39.00

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 993.20

LogP -11.35

H-bond Donors 35.0

H-bond Acceptors 38.0

Rotatable Bonds 73.0

Heavy Atoms 167.0

Ring Count 6.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0225004 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/