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MYP_133298
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Basic Information
Brevinin-2EC
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
34 amino acids
C154H267N43O46S2
Standard
Sequence
GILLDKLKNFAKTAGKGVLQSLLNTASCKLSGQC
Physicochemical Analysis
3521.16 Da
9.60
3.74
3.50
0.1099
0.18
0.65
0.09
20.86
109.12
0.0294
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1464.53
-16.75
52.0
52.0
125.0
245.0
1.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0207242 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive and Gram-negative bacteria
PaperPubMed PMID: 8163497 | PubMed PMID: 16394170 PMID8163497;16394170 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/
RECORD: Rec_0212305 VERIFIED: YES
Provenance & Taxonomy
Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
28-34
Bio-Activity Profile
Antimicrobial Antibacterial
PaperM.F. Ali et al. / Peptides 24 (2003) 955-961. Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex Evidence URLhttps://www.uniprot.org/uniprotkb/P40839/entry
RECORD: Rec_0229392 VERIFIED: NO
Provenance & Taxonomy
Pelophylax lessonae [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic Non-ribosomal
Gram-negative bacteria; Gram-positive bacteria
Qualitative functional evidence
PMID8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/; https://www.uniprot.org/uniprotkb/P40839/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0251712 VERIFIED: YES
Provenance & Taxonomy
Edible frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
28-34
Bio-Activity Profile
Antimicrobial
PMID8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/
RECORD: Rec_0256343 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Gram-negative and Gram-positive bacteria
PMID18280749;18855342 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18280749/
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