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MYP_133278
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Basic Information
LEDGF-(360-70)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
11 amino acids
C59H93N15O19
Standard
Sequence
WNSLKIDNLDV
Physicochemical Analysis
1316.46 Da
4.21
-1.24
-1.44
-0.1126
-0.30
0.07
0.03
4.87
132.73
0.0909
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
577.14
-4.41
19.0
18.0
43.0
93.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017962 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
11.9 μM
IC50
PaperAffinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex. PMID19801648 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19801648/
RECORD: Rec_0079591 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
0.1 μM
% inhibition
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperMechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. | Hayouka Z, Levin A, Maes M, Hadas E, Shalev DE, Volsky DJ, Loyter A, Friedler A. | Biochem Biophys Res Commun. 2010 Apr 2;394(2):260-5. | DOI:10.1016/j.bbrc.2010.02.100 | PMID:20171172 PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
RECORD: Rec_0096983 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
Qualitative inhibition
PaperCyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein. PMID20974536 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20974536/
RECORD: Rec_0098614 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1
PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
RECORD: Rec_0102371 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
Sup-T1
81 %
Inhibition
PaperMechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
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