Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2575H3995N635O748S17

DescriptionStandard

        MRMKEVPVLWGCFLLWSLYISSSQTMYPGIKARVTQRALDYAVQAGLEMIEDMIKEKNLPDLNGSESLEFLKIDYVDYNFSNIKINAFSFPNTSLAFVPGVGIKVLTNHGTTNISTNWAIKSPLFQDSGGADLFLSEIYFTGIIILTQNEFGHPVLKLQDCYAQASHAHVSFSGELSVLYNSFAEPMEKPILKNLNGMLCPIITNEVEALNVNLSTLEVITKINNYTLVDFSLVGPPEITEHYLDLNLKGVFYPLENLVDPPFSPVPFELPDRGDSMIYIGVSEYFFKSASFAHFTAGAFGITLSTKEISKHFIQNSQGLGTVLSQIAEIYILSQPFMLQIMATEPPTVNLQPGNFTLDIPASIMMLTQPENSTLQSIVSMDFVASTSVGLAILGQRLICSLSLKRFRLSLPESSRNDIKVVRFENILSSILHFGVLPLANTRLQQGFPLPNPHKLSFVNSDIEVLEGFLLISTDLKYESPSKQQPSFHGWEDLSLLNGQWTGKATP
    

Molecular Weight56361.17 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-15.60

Net Charge (pH 7.4) -16.50

Charge Density (pH 7.0) -0.0308

GRAVY Index0.11

Hydrophobic Moment 0.69

Boman Index0.18

Instability Index37.66

Aliphatic Index 101.12

Aromaticity 0.1026

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0298296 VERIFIED: NO

Provenance & Taxonomy

OrganismSpermophilus dauricus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence