Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length485 amino acids

Chemical FormulaC2436H3875N641O671S17

DescriptionStandard

        TKMARGADNTLRWATLVALAALGTAVTAAANPGIVARITQKGLDYACQQGVATLRKELEKITIPTFSGSFKIKYFGKGRYNFYSMVVRGFKLPTSQIRLSPDRGLDLSIKDASVKISGKWKAQKNFIKASGNFDLSVEGISVLASLRLGYDPTSGHSTVSCSSCRSHINRVHVRTSGSSLKWLIQLFHRNIESALRKAMESKICKMLTNTVSSKLQPYFQTLPVTAKVDRMVGINYSLVAPPKATAENLDGLLKGEFFSLDHPSPPPFAPPALALPADHDRMVYLCISEYFFNTAGLVYQKAGVLNLTISNSMIPKKSLFSLTTNFFGTLIPKVSTMFPNMEMQFLIWASFPPHLTVHPSGLDLTFVLETQAFAVLPNASLAPLFLIEMNSSISVDIGVRSKRLIGELRLNKLLLELKHSNIGPFSVELLQAVMNFAVPTLVLPKINEKLQRGFPLPLPAYIQLSNLVLQPHQDFLLFGADVRYS
    

Molecular Weight53422.82 Da

Isoelectric Point (pI)9.76

Net Charge (pH 7.0)21.24

Net Charge (pH 7.4) 20.37

Charge Density (pH 7.0) 0.0438

GRAVY Index0.12

Hydrophobic Moment 0.81

Boman Index0.12

Instability Index32.60

Aliphatic Index 100.14

Aromaticity 0.0907

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221629 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBPI/LBP

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence