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MYP_133112
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Basic Information
Rabbit neutrophil defensin 3a
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Standard
34 amino acids
C163H265N63O44S6
Standard
Sequence
GICACRRRFCPNSERFSGYCRVNGARYVRCCSRR
Physicochemical Analysis
4003.63 Da
10.20
7.70
7.41
0.2265
-0.64
0.77
-0.43
76.04
34.41
0.1176
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1796.56
-23.88
75.0
58.0
130.0
276.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198811 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Defensin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0248062 VERIFIED: NO
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
9986
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-31; 5-20; 10-30
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0344589 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 58.8%, T 17.6%, C 23.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiviral Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0348994 VERIFIED: NO
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperPatent US 2008/0269122 A1 Evidence URLhttps://patents.google.com/patent/US20080269122A1/en PatentUS 2008/0269122 A1
RECORD: Rec_0376106 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bridges
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Staphylococcus aureus strains 566, 502A, J.F. (reduction 0-1.3 logs), Staphylococcus epidermidis UCLA-622 (reduction 1.3 logs), S. pneumoniae Type III (reduction >3.5 log), S. agalactiae Type I-A
PaperPrimary structures of six antimicrobial peptides of rabbit peritoneal neutrophils
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