Peptide Database

Peptide NameDermaseptin-S1 (1-15)[W3H]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC74H134N20O18S2

DescriptionStandard

        ALHKTMLKKLGTMAL
    

Molecular Weight1656.11 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)2.88

Net Charge (pH 7.4) 2.64

Charge Density (pH 7.0) 0.1920

GRAVY Index0.39

Hydrophobic Moment 0.48

Boman Index0.15

Instability Index16.37

Aliphatic Index 117.33

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 617.92

LogP -3.34

H-bond Donors 22.0

H-bond Acceptors 24.0

Rotatable Bonds 59.0

Heavy Atoms 114.0

Ring Count 1.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0093627 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDermaseptin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHSV-1:inhibition of virus infection in Vero cells

Activity5 μM

MethodIC50

RECORD: Rec_0100697 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDermaseptin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral Hemolytic

Targethuman red cells

Activity100 μM

MethodHC50

RECORD: Rec_0123880 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDermaseptin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal

TargetTrichomonas vaginalis SS22

Activity95 μM

MethodLC50

RECORD: Rec_0136820 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDermaseptin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal

TargetStaphylococcus aureus ATCC 6538P

Activity45 μM

MethodMIC

RECORD: Rec_0139009 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDermaseptin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal

TargetEscherichia coli HB101

Activity44.9 μM

MethodMIC

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