Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length197 amino acids

Chemical FormulaC986H1536N254O294S13

DescriptionStandard

        MQRLMFLLMLTQSCADNPAFKALLSEKALTDLSQMMPVWIQSKMKSTAIPDIHDQVDIGIGWVNYVLSHMRVVQCETAEPSLVFVEGTGLYLEVRELSLAVSGRWRTKFGIITDSGSFDVEVYNIYIRVVLGVGDKDGHLSISSESCSNDVGNVYIQFHGGTSFFYQLFEDYFSGKASDMIRQKICPAIQQAVTNME
    

Molecular Weight22069.11 Da

Isoelectric Point (pI)5.05

Net Charge (pH 7.0)-7.16

Net Charge (pH 7.4) -7.69

Charge Density (pH 7.0) -0.0363

GRAVY Index0.09

Hydrophobic Moment 0.56

Boman Index0.13

Instability Index32.84

Aliphatic Index 92.94

Aromaticity 0.1015

Extinction Coeff. Reduced 26930.00

Extinction Coeff. Oxidized 27180.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8787.70

LogP -104.61

H-bond Donors 307.0

H-bond Acceptors 304.0

Rotatable Bonds 710.0

Heavy Atoms 1547.0

Ring Count 32.0

Amide Bonds 213.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0331938 VERIFIED: YES

Provenance & Taxonomy

OrganismDanio rerio [Animal]

FamilyBPI/LBP

Tax ID7955

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria