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MYP_133010
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Basic Information
Bacteriocin uberolysin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
70 amino acids
C324H534N82O93
Standard
Sequence
LAGYTGIASGTAKKVVDAIDKGAAAFVIISIISTVISAGALGAVSASADFIILTVKNYISRNLKAQAVIW
Physicochemical Analysis
7066.20 Da
9.60
2.76
2.54
0.0394
0.94
0.72
0.37
-2.28
132.57
0.0714
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2783.17
-25.88
99.0
96.0
234.0
499.0
6.0
72.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0092170 VERIFIED: YES
Provenance & Taxonomy
Streptococcus uberis [Bacterium]
2; 2
Structure & Mods
head-to-tail cyclic bacteriocin [Cyclic]
canonical L-amino-acid peptide [L]
Head-to-tail cyclized to C terminus
Head-to-tail cyclized to N terminus
Head-to-tail backbone cyclization of mature 70-aa peptide (precursor Leu7–Trp76 bond)
Bio-Activity Profile
Antimicrobial
susceptible Gram-positive bacteria including streptococci, enterococci, staphylococci, lactococci and Listeria species
deferred antagonism, agar spot inhibition, and liquid-culture growth/lysis assays
PaperWirawan RE et al. Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology. 2007;153:1619-1630. doi:10.1099/mic.0.2006/005967-0. PMID17464077;19939484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19939484/
RECORD: Rec_0129344 VERIFIED: YES
Provenance & Taxonomy
Streptococcus uberis [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic bacteriocin [Cyclic]
canonical L-amino-acid peptide [L]
Head-to-tail cyclized to C terminus
Head-to-tail cyclized to N terminus
Head-to-tail backbone cyclization of mature 70-aa peptide (precursor Leu7–Trp76 bond)
Bio-Activity Profile
Antimicrobial Antibacterial
Most streptococci (except Streptococcus rattus and Streptococcus mutans)
deferred antagonism activity-spectrum assay
PaperWirawan RE et al. Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology. 2007;153:1619-1630. doi:10.1099/mic.0.2006/005967-0. PMID17464077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17464077/
RECORD: Rec_0131531 VERIFIED: YES
Provenance & Taxonomy
Streptococcus uberis [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic bacteriocin [Cyclic]
canonical L-amino-acid peptide [L]
Head-to-tail cyclized to C terminus
Head-to-tail cyclized to N terminus
Head-to-tail backbone cyclization of mature 70-aa peptide (precursor Leu7–Trp76 bond)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Streptococcus pyogenes 71-698
deferred antagonism / agar spot inhibition assay
PaperWirawan RE et al. Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology. 2007;153:1619-1630. doi:10.1099/mic.0.2006/005967-0. PMID17464077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11555873/
RECORD: Rec_0133676 VERIFIED: YES
Provenance & Taxonomy
Streptococcus uberis [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic bacteriocin [Cyclic]
canonical L-amino-acid peptide [L]
Head-to-tail cyclized to C terminus
Head-to-tail cyclized to N terminus
Head-to-tail backbone cyclization of mature 70-aa peptide (precursor Leu7–Trp76 bond)
Bio-Activity Profile
Antimicrobial Antibacterial
Listeria spp
deferred antagonism activity-spectrum assay
PaperWirawan RE et al. Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology. 2007;153:1619-1630. doi:10.1099/mic.0.2006/005967-0. PMID17464077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17464077/
RECORD: Rec_0136040 VERIFIED: YES
Provenance & Taxonomy
Streptococcus uberis [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic bacteriocin [Cyclic]
canonical L-amino-acid peptide [L]
Head-to-tail cyclized to C terminus
Head-to-tail cyclized to N terminus
Head-to-tail backbone cyclization of mature 70-aa peptide (precursor Leu7–Trp76 bond)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus lactis A5
deferred antagonism / agar spot inhibition assay
PaperWirawan RE et al. Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology. 2007;153:1619-1630. doi:10.1099/mic.0.2006/005967-0. PMID17464077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11555873/
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