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MYP_133002
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Basic Information
Dermaseptin PD-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
31 amino acids
C141H241N39O43S3
Standard
Sequence
GMWSKIKETAMAAAKEAAKAAGKTISDMIKQ
Physicochemical Analysis
3266.85 Da
9.70
2.76
2.55
0.0891
-0.27
0.67
0.00
10.33
63.55
0.0323
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1344.14
-13.52
47.0
49.0
117.0
226.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0276264 VERIFIED: YES
Provenance & Taxonomy
Pachymedusa dacnicolor [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antibacterial
Escherichia coli
19.6 μM
MIC
PaperShi D et al. Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor. Toxins. 2016;8:144. doi:10.3390/toxins8050144. PMID27187467
RECORD: Rec_0307850 VERIFIED: YES
Provenance & Taxonomy
Pachymedusa dacnicolor [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer
Human prostate adenocarcinoma PC-3
MTT cell-proliferation assay; no inhibition observed at tested concentrations
PaperShi D et al. Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor. Toxins. 2016;8:144. doi:10.3390/toxins8050144. PMID27187467 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27187467/
RECORD: Rec_0320806 VERIFIED: YES
Provenance & Taxonomy
Pachymedusa dacnicolor [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer
Pseudomonas aeruginosa ATCC 27853
78.4 μM
MBC
PaperShi D et al. Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor. Toxins. 2016;8:144. doi:10.3390/toxins8050144. PMID27187467 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27187467/
RECORD: Rec_0335719 VERIFIED: YES
Provenance & Taxonomy
Pachymedusa dacnicolor [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer
Pseudomonas aeruginosa ATCC 27853
19.6 μM
MIC
PaperShi D et al. Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor. Toxins. 2016;8:144. doi:10.3390/toxins8050144. PMID27187467 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27187467/
RECORD: Rec_0383898 VERIFIED: YES
Provenance & Taxonomy
Pachymedusa dacnicolor [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer
Staphylococcus aureus NCTC 10788
78.4 μM
MBC
PaperShi D et al. Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor. Toxins. 2016;8:144. doi:10.3390/toxins8050144. PMID27187467 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27187467/
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