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MYP_132836
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Tubulin-Tyrosine Ligase Inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
2 amino acids
C18H20N2O5
Standard
Sequence
YY
Physicochemical Analysis
344.36 Da
5.52
-0.24
-0.45
-0.1210
-1.30
0.17
0.26
66.70
0.00
1.0000
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
132.88
0.78
5.0
5.0
7.0
25.0
2.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0244609 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Model sensory peptide
32630
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
0.43 Rcaf
Relative bitterness (Rcaf)
PaperBitterness of phenylalanine- and tyrosine-containing peptides. Agric. Biol. Chem., 51, 3309-3313, 1987
RECORD: Rec_0249797 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperQuantitative structure-activity relationship study of bitter di- and tri-peptides including relationship with angiotensin I-converting enzyme inhibitory activity. PMID17117396 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17117396/
RECORD: Rec_0255383 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
9 μM
IC50
Rat plasma, in vitro; 960 s
PMID14980787 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14980787/
RECORD: Rec_0420368 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
human dipeptidyl peptidase IV
PaperLan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.. Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015. PMID25577052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25577052/
RECORD: Rec_0422330 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
180.0
IC50
PaperLafarga T, Aluko RE, Rai DK, O'Connor P, Hayes M.. Identification of bioactive peptides from a papain hydrolysate of bovine serum albumin and assessment of an antihypertensive effect in spontaneously hypertensive rats. Food Res Int. 81, 91-99, 2016.
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