Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length506 amino acids

Chemical FormulaC2486H3947N707O735S25

DescriptionStandard

        MQQAMAGTGDAAGHGGDWRCSRPWRGLEMQALRRLEMQARRRRLEQRARWQRLEPLEEGSSPFPHTLSKSPLTQERTQPKVERARRRLERAWSSSSSSSYWTQRRCVGPAEHRGTNHWRGMWRRTEIDELARTPVSLGGLDEMNSYYPEPLQPRTWSYLNTKNGQGDTNYEAQFLNVFVLNAGRQIGITSIQQKLRSMKVPDISGTEKVDPIGKVQYSFTGMQIVNLGLPKSALDLVPDTGVMLSIGQANINLHGNWRVKYLRIIKDSGSFDLAVGELAISTTIAVMSDDTGRPTVSMTNCAATVGSVNVKFHGGASSFINKALRSALQKQGEFYNIGQHKEPPFSPTPFSLPYQDTNMLYIGVSAFSLNSAGFVYHNAGALRLYITDDMIAKMYPGLMMKLMVETVKEPIIIFEPNNMTIQASSTVTAYAIQPNSTLSSLFVLNLEGSVSADIYVTELKLAGNLTLNNLMSYTVLLVLSCSQALAFPVPRLDACLALLCLLHQRP
    

Molecular Weight56300.85 Da

Isoelectric Point (pI)9.32

Net Charge (pH 7.0)11.28

Net Charge (pH 7.4) 10.42

Charge Density (pH 7.0) 0.0223

GRAVY Index-0.27

Hydrophobic Moment 0.84

Boman Index0.01

Instability Index45.21

Aliphatic Index 84.05

Aromaticity 0.0791

Extinction Coeff. Reduced 73340.00

Extinction Coeff. Oxidized 73715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0152368 VERIFIED: NO

Provenance & Taxonomy

OrganismAnabarilius grahami [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence