Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC133H193N31O42

DescriptionStandard

        IEEQAKTFLDKFQHEVEEIYWQS
    

Molecular Weight2898.14 Da

Isoelectric Point (pI)4.41

Net Charge (pH 7.0)-4.14

Net Charge (pH 7.4) -4.41

Charge Density (pH 7.0) -0.1800

GRAVY Index-0.95

Hydrophobic Moment 0.59

Boman Index-0.08

Instability Index90.03

Aliphatic Index 67.83

Aromaticity 0.1739

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1213.79

LogP -7.77

H-bond Donors 40.0

H-bond Acceptors 39.0

Rotatable Bonds 98.0

Heavy Atoms 206.0

Ring Count 6.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0129691 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antibacterial Antimicrobial Antiviral

RECORD: Rec_0364036 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsContains non-standard symbols/residues: -.

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Entry inhibition

TargetSARS-CoV-2 | HEK293T/ACE2 cells

Activity0.011±0.001 μM

MethodIC50

Half-LifeMammalian: 20 h; Yeast: 30 min; E. coli: >10 h

PaperSynthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein | Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR. | J Med Chem. 2022 Feb 24;65(4):2836-2847. | DOI:10.1021/acs.jmedchem.1c00477 | PMID:34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/