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MYP_132813
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Basic Information
Nigrocin-RE1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
21 amino acids
C86H155N23O24S2
Standard
Sequence
GLLSGILGAGKKIVCGLSGLC
Physicochemical Analysis
1959.42 Da
8.90
1.74
1.50
0.0828
1.30
0.48
0.47
-1.52
148.57
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
737.82
-7.02
28.0
28.0
68.0
135.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0325305 VERIFIED: NO
Provenance & Taxonomy
Odorrana macrotympana [Animal] [Animal]; Rana exilispinosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0364665 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Nigrocin
156873
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 25923
10 μg/mL
MIC
PaperNovel peptides from skins of amphibians showed broad-spectrum antimicrobial activities.
RECORD: Rec_0399851 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Clinical MRSA strains
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
125.4
MIC
PMID30555431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30555431/
RECORD: Rec_0402198 VERIFIED: YES
Provenance & Taxonomy
Little spiny [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID26452973 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26452973/
RECORD: Rec_0420663 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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