Peptide Database

Peptide NameSLAY-screened peptide P5337

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H171N27O29S2

DescriptionStandard

        YTCPTMPPYHLITLYSNRKL
    

Molecular Weight2411.84 Da

Isoelectric Point (pI)9.11

Net Charge (pH 7.0)1.83

Net Charge (pH 7.4) 1.56

Charge Density (pH 7.0) 0.0917

GRAVY Index-0.32

Hydrophobic Moment 0.25

Boman Index0.05

Instability Index48.41

Aliphatic Index 78.00

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 891.15

LogP -5.79

H-bond Donors 32.0

H-bond Acceptors 34.0

Rotatable Bonds 70.0

Heavy Atoms 169.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0322240 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/