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MYP_132802
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Basic Information
Pardaxin P-2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
33 amino acids
C154H248N36O45
Standard
Sequence
GFFALIPKIISSPIFKTLLSAVGSALSSSGGQE
Physicochemical Analysis
3323.83 Da
8.59
0.77
0.56
0.0232
0.77
0.50
0.38
39.52
112.42
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1271.21
-13.02
44.0
46.0
108.0
235.0
5.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019032 VERIFIED: NO
Provenance & Taxonomy
Pardachirus pavoninus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Toxin
RECORD: Rec_0049347 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 57.6%, E 0.0%, T 30.3%, C 12.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Anti-Gram-positive Cytotoxic Anti-Gram-negative
PaperIn silico approach for predicting toxicity of peptides and proteins PMID24058508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24058508/
RECORD: Rec_0120081 VERIFIED: YES
Provenance & Taxonomy
Sea moses sole [Animal]
Pardaxin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperMelittin-Like Peptides from the Shark-Repelling Defense Secretion of the Sole Pardachirus pavoninus
RECORD: Rec_0122223 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0170430 VERIFIED: YES
Provenance & Taxonomy
Pardachirus pavoninus [Plant]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
PaperPubMed PMID: 17737623 | PubMed PMID: 1868074 PMID17737623;1868074 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17737623/
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