Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length178 amino acids

Chemical FormulaC875H1442N264O242S5

DescriptionStandard

        QKGLDYACQQGVAVLQKELEKIRIPDVSGKFKLRPFGKGHYNFHSLVVRSFQLPNPQIRLQPNVGLRVSISNANVRIGGRWKARKGFIKVRGKFDLSVEGVSISADLKLGSVPASGRATVTCSSCSSNINRARLRVSGILGWLLKLFHKRIESSLRNTMNSKICQVLTSSVSSKLQPY
    

Molecular Weight19692.76 Da

Isoelectric Point (pI)10.89

Net Charge (pH 7.0)21.98

Net Charge (pH 7.4) 21.53

Charge Density (pH 7.0) 0.1235

GRAVY Index-0.20

Hydrophobic Moment 0.66

Boman Index-0.05

Instability Index48.23

Aliphatic Index 96.29

Aromaticity 0.0674

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15720.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8249.60

LogP -101.45

H-bond Donors 296.0

H-bond Acceptors 272.0

Rotatable Bonds 672.0

Heavy Atoms 1386.0

Ring Count 24.0

Amide Bonds 195.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0198842 VERIFIED: NO

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

Tax ID9986

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence