Peptide Database

Peptide NameDefensin-1 (Royalisin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length95 amino acids

Chemical FormulaC471H739N131O135S10

DescriptionStandard

        MKIYFIVGLLFMAMVAIMAAPVEDEFEPLEHFENEERADRHRRVTCDLLSFKGQVNDSACAANCLSLGKAGGHCEKGVCICRKTSFKDLWDKRFG
    

Molecular Weight10717.35 Da

Isoelectric Point (pI)6.27

Net Charge (pH 7.0)-1.28

Net Charge (pH 7.4) -1.76

Charge Density (pH 7.0) -0.0134

GRAVY Index-0.08

Hydrophobic Moment 0.53

Boman Index0.01

Instability Index35.04

Aliphatic Index 77.05

Aromaticity 0.0947

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4272.68

LogP -37.20

H-bond Donors 154.0

H-bond Acceptors 147.0

Rotatable Bonds 362.0

Heavy Atoms 747.0

Ring Count 15.0

Amide Bonds 98.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0070622 VERIFIED: YES

Provenance & Taxonomy

OrganismApis mellifera [Animal]

FamilyDefensin

Tax ID7460

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-positive Hemolytic

TargetGram-positive bacteria

RECORD: Rec_0244667 VERIFIED: YES