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MYP_132652
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Basic Information
Alisporivir, Debio-025
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXXVXAAXXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0318718 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
Human hepatocellular carcinoma Huh7
50-60 % Cytotoxicity
Cytotoxicity
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0353483 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
Human colon adenocarcinoma Caco-2
20-30 % Cytotoxicity
Cytotoxicity
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0391097 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
Transmissible gastroenteritis coronavirus (TGEV/PCoV)
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0395944 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
mixed L/D amino-acid peptide [Mixed]
not reported
not reported
The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | E6 cells
4.9±1.3 μM
EC50
PaperSARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology. | Ogando NS, Dalebout TJ, Zevenhoven-Dobbe JC, Limpens RWAL, van der Meer Y, Caly L, Druce J, de Vries JJC, Kikkert M, Bárcena M, Sidorov I, Snijder EJ. | J Gen Virol. 2020 Sep;101(9):925-940. | DOI:10.1099/jgv.0.001453 | PMID:32568027 PMID32568027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32568027/
RECORD: Rec_0401283 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
mixed L/D amino-acid peptide [Mixed]
not reported
not reported
The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | E6 cells
3.1±1.4 μM
EC90
PaperInhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025). | Softic L, Brillet R, Berry F, Ahnou N, Nevers Q, Morin-Dewaele M, Hamadat S, Bruscella P, Fourati S, Pawlotsky JM, Ahmed-Belkacem A. | Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00876-20. | DOI:10.1128/AAC.00876-20 | PMID:32376613 PMID32376613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376613/
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