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MYP_132652
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Basic Information
Alisporivir, Debio-025
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXXVXAAXXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0265040 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
X(1)=alpha-Aminobutyrate; X(2)=Sarcosine; X(3)=METH-Leu; X(5)=METH-Leu; X(7)=D-Ala; X(8)=METH-Leu; X(9)=METH-Leu; X(10)=METH-Val; X(11)=N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antimicrobial Anticancer
CaCo-2 ; 20% Killing=17μM
0 %
Cytotoxicity
PaperPubMed PMID: 28137809 PMID28137809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28137809/
RECORD: Rec_0278052 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
SARS-CoV-2 Australia/VIC01/2020
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0290143 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
X(1)=alpha-Aminobutyrate; X(2)=Sarcosine; X(3)=METH-Leu; X(5)=METH-Leu; X(7)=D-Ala; X(8)=METH-Leu; X(9)=METH-Leu; X(10)=METH-Val; X(11)=N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antimicrobial Anticancer
Huh-7 ; 50% Killing=17μM
0 %
Cytotoxicity
PaperPubMed PMID: 28137809 PMID28137809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28137809/
RECORD: Rec_0304192 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Hemolytic
Vero E6 cells
>20 μM
Cytotoxicity
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0314982 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
No specific N-terminal
No specific C-terminal
The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
Vero E6 cells
20 μM
CC50
PMID32376613;32568027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376613/
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