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MYP_132652
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Basic Information
Alisporivir, Debio-025
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXXVXAAXXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0208375 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Fungus]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
SARS-CoV
coronavirus replication/infection inhibition assay
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0232358 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
mixed L/D amino-acid peptide [Mixed]
not reported
not reported
The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antiviral Anti-SARS-CoV Infection inhibition
SARS-CoV; E6 cells
4.3±1 μM
EC50
PaperSARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology. | Ogando NS, Dalebout TJ, Zevenhoven-Dobbe JC, Limpens RWAL, van der Meer Y, Caly L, Druce J, de Vries JJC, Kikkert M, Bárcena M, Sidorov I, Snijder EJ. | J Gen Virol. 2020 Sep;101(9):925-940. | DOI:10.1099/jgv.0.001453 | PMID:32568027 PMID32568027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32568027/
RECORD: Rec_0252487 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Fungus]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
SARS-CoV-2
coronavirus replication/infection inhibition assay
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0265040 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Fungus]
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
X(1)=alpha-Aminobutyrate; X(2)=Sarcosine; X(3)=METH-Leu; X(5)=METH-Leu; X(7)=D-Ala; X(8)=METH-Leu; X(9)=METH-Leu; X(10)=METH-Val; X(11)=N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antimicrobial Anticancer
human Caco-2 cells
0 %
cytotoxicity/killing assay at 17 μM
PaperPubMed PMID: 28137809 PMID28137809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28137809/
RECORD: Rec_0278052 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Fungus]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
SARS-CoV-2 Australia/VIC01/2020
coronavirus replication/infection inhibition assay
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
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