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MYP_132652
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Basic Information
Alisporivir, Debio-025
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXXVXAAXXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0107842 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
Human colon adenocarcinoma Caco-2
0-10 % Cytotoxicity
Cytotoxicity
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0108186 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Hemolytic
Vero E6 cells
<10 % Killing
Killing
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
RECORD: Rec_0120680 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
mixed L/D amino-acid peptide [Mixed]
not reported
not reported
The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | E6 cells
0.46±0.04 μM
EC50
PaperInhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025). | Softic L, Brillet R, Berry F, Ahnou N, Nevers Q, Morin-Dewaele M, Hamadat S, Bruscella P, Fourati S, Pawlotsky JM, Ahmed-Belkacem A. | Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00876-20. | DOI:10.1128/AAC.00876-20 | PMID:32376613 PMID32376613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376613/
RECORD: Rec_0123442 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
No specific N-terminal
No specific C-terminal
The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus
PMID32376613;32568027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376613/
RECORD: Rec_0135120 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Antiviral
HIV-1
PMID22046132 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22046132/
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