MYP_132652
Alisporivir, Debio-025
Anticancer
Anticancer
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Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antiviral
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Anti-Coronavirus
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Antiviral
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Anti-Coronavirus
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Enzyme modulation
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Enzyme inhibition
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Infection inhibition
Membrane / Ion-channel modulation
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Sodium channel modulation
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Sodium channel inhibitor
Toxicity / Safety
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Blood cell toxicity
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Hemolysis
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Hemolytic
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Venom / Toxin
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General toxin
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Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
XXXVXAAXXXX
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0000875
VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
HCoV-NL63
RECORD: Rec_0010736
VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
Infectious bronchitis virus (IBV/ACoV)
RECORD: Rec_0075278
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
No specific N-terminal
No specific C-terminal
The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antimicrobial
Anti-SARS-CoV-2
SARS-CoV:Inhibition of infection in Vero E6 cells
4.3±1 μM
EC50
RECORD: Rec_0076749
VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 1,2,3,5,8,9,10,11
Bio-Activity Profile
SARS-CoV Frank
RECORD: Rec_0078778
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
No specific N-terminal
No specific C-terminal
The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl
Bio-Activity Profile
Antimicrobial
Anti-SARS-CoV-2
SARS-CoV-2:Inhibition of infection in Vero E6 cells
4.9±1.3 μM
EC50
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