Peptide Database

Peptide NameDA GLP-1 (Lys20,28)-PEG-Fc

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC182H275N43O59S2

DescriptionStandard

        VEGTFTSDVSSYLEEQAAKEFIAWLIKGGPSSGAPPPCC
    

Molecular Weight4073.51 Da

Isoelectric Point (pI)4.25

Net Charge (pH 7.0)-3.28

Net Charge (pH 7.4) -3.53

Charge Density (pH 7.0) -0.0840

GRAVY Index-0.04

Hydrophobic Moment 0.48

Boman Index0.19

Instability Index51.52

Aliphatic Index 65.13

Aromaticity 0.1026

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1593.22

LogP -16.86

H-bond Donors 55.0

H-bond Acceptors 58.0

Rotatable Bonds 125.0

Heavy Atoms 286.0

Ring Count 9.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0424979 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGLP-1

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermModification of His1 of Exendin-4 into desaminohistidyl (DA) group

C-TermAddition of Fc

Other ModsPegylation at K20 and K28

Bio-Activity Profile

Function

Insulinotropic

MethodEC50

Half-Lifeblood; 97200 s