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MYP_132611
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Basic Information
29(derived from HCV C5A)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Antiviral ▸ Virucidal activity
Standard
18 amino acids
C108H155N25O27S
Standard
Sequence
DWLRIIWDWVCSVVSDFK
Physicochemical Analysis
2267.60 Da
4.43
-1.25
-1.47
-0.0693
0.42
0.64
0.22
9.74
113.33
0.2222
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
845.67
-2.11
32.0
27.0
69.0
161.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025957 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
5
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0117201 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
cells
0.55 μM
IC50
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0194742 VERIFIED: YES
Provenance & Taxonomy
Hepatitis C virus [Virus]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal
Hepatitis C virus (Viral membrane); Huh7
0.55 μM
RT-PCR
PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0215034 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Release inhibition
Hepatitis C virus (HCV) | Huh-7.5.1 cells
0.55 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-93. | DOI:10.1073/pnas.0712380105 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0275488 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
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