Peptide Database

Peptide NameSLAY-screened peptide P5429

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC83H124N20O22S

DescriptionStandard

        HCLELSPNYSLIHFL
    

Molecular Weight1786.06 Da

Isoelectric Point (pI)5.98

Net Charge (pH 7.0)-1.07

Net Charge (pH 7.4) -1.40

Charge Density (pH 7.0) -0.0716

GRAVY Index0.47

Hydrophobic Moment 0.22

Boman Index0.32

Instability Index52.78

Aliphatic Index 130.00

Aromaticity 0.1333

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 660.37

LogP -3.30

H-bond Donors 23.0

H-bond Acceptors 24.0

Rotatable Bonds 54.0

Heavy Atoms 126.0

Ring Count 5.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0171305 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/