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MYP_132550
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Basic Information
Lactoglobulin beta [078-082]
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
5 amino acids
C28H43N5O6
Standard
Sequence
IPAVF
Physicochemical Analysis
545.67 Da
5.53
-0.24
-0.44
-0.0480
2.34
0.45
0.88
40.76
156.00
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
170.93
0.81
5.0
6.0
13.0
39.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0064095 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Taste Enzyme inhibitory ACE inhibitory
Angiotensin-I converting enzyme
9.09 μM
IC50
RECORD: Rec_0085673 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
PaperIdentification of bitter peptides in whey protein hydrolysate. J. Agric. Food Chem., 62, 5719-5725, 2014 PMID23998904 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23998904/
RECORD: Rec_0105088 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
5.3±0.1 μg/mL
IC50
PaperANGIOTENSIN I-CONVERTING ENZYME (ACE) INHIBITORY PEPTIDES FROM WHEY FERMENTED BY LACTOBACILLUS SPECIES
RECORD: Rec_0120409 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
PaperGambacorta N., Caputo L., Quintieri L., Monaci L., Ciriaco F., Nicolotti O.. Rational discovery of antiviral whey protein-derived small peptides targeting the SARS-CoV-2 main protease. Biomedicines, 10, 1067, 2022.
RECORD: Rec_0166951 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Lactoglobulin-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
9.09 μM
IC50
PaperStructure-Based Identification and Design of Angiotensin Converting Enzyme-Inhibitory Peptides from Whey Proteins | Tondo, AR. et al. | DOI: 10.1021/acs.jafc.9b06237 Evidence URLhttps://www.uniprot.org/uniprotkb/P02754/entry
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