Peptide Database

Peptide NamePhospholipase A2; membrane associated (EC 3.1.1.4) (Enhancing factor) (EF) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Bacteriolytic activity ▸ Bacteriolytic enzyme

Enzyme / Catalytic activity ▸ Hydrolase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length146 amino acids

Chemical FormulaC701H1122N200O201S18

DescriptionStandard

        MKVLLLLAASIMAFGSIQVQGNIAQFGEMIRLKTGKRAELSYAFYGCHCGLGGKGSPKDATDRCCVTHDCCYKSLEKSGCGTKLLKYKYSHQGGQITCSANQNSCQKRLCQCDKAAAECFARNKKTYSLKYQFYPNMFCKGKKPKC
    

Molecular Weight16144.80 Da

Isoelectric Point (pI)9.37

Net Charge (pH 7.0)15.61

Net Charge (pH 7.4) 14.99

Charge Density (pH 7.0) 0.1069

GRAVY Index-0.37

Hydrophobic Moment 0.45

Boman Index-0.06

Instability Index26.16

Aliphatic Index 59.59

Aromaticity 0.0959

Extinction Coeff. Reduced 11920.00

Extinction Coeff. Oxidized 12795.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6533.55

LogP -71.89

H-bond Donors 241.0

H-bond Acceptors 238.0

Rotatable Bonds 554.0

Heavy Atoms 1120.0

Ring Count 20.0

Amide Bonds 159.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0145313 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyPhospholipase A2

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriolytic enzyme Anti-Gram-positive Hydrolase Non-hemolytic

TargetGram Positive Bacteria