Peptide Database

Peptide NameUnnamed

Function Ontology

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Standard StatusStandard

Sequence Length73 amino acids

Chemical FormulaC343H554N96O117S6

DescriptionStandard

        ECSQDCAACSYRLVRPGDLNFLACTLECEGQLPSLKIWETCKDLLQVSKQELPQEGASSLRESGKQDESHLLS
    

Molecular Weight8087.03 Da

Isoelectric Point (pI)4.64

Net Charge (pH 7.0)-5.12

Net Charge (pH 7.4) -5.45

Charge Density (pH 7.0) -0.0701

GRAVY Index-0.45

Hydrophobic Moment 0.62

Boman Index-0.08

Instability Index76.22

Aliphatic Index 82.88

Aromaticity 0.0411

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3458.39

LogP -39.92

H-bond Donors 123.0

H-bond Acceptors 119.0

Rotatable Bonds 275.0

Heavy Atoms 562.0

Ring Count 8.0

Amide Bonds 79.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0197330 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0327398 VERIFIED: NO

Provenance & Taxonomy

OrganismCavia porcellus [Animal]

FamilyOpioid

Tax ID10141

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Opioid Analgesic Neuromodulator

RECORD: Rec_0354318 VERIFIED: YES

Provenance & Taxonomy

OrganismCavia porcellus [Animal]

FamilySynenkephalin

Tax ID10141

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-24; 6-28; 9-41

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour