‹ ›
MYP_132222
← PREVIOUS NEXT → BACK
Basic Information
D-LAK120-A
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
25 amino acids
C131H236N34O26
Standard
Sequence
KKLALALAKKWLALAKKLALALAKK
Physicochemical Analysis
2703.49 Da
10.85
7.75
7.54
0.3101
0.51
0.56
0.09
7.74
156.80
0.0400
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
985.67
-1.68
35.0
34.0
99.0
191.0
2.0
24.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0339010 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
D-LAK120-A
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum 3D7
1.45±0.12 μM
IC50; Fluorimetry (SYBR Green II)
PaperConformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic alpha-helical peptides PMID22869378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22869378/
RECORD: Rec_0351919 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium tuberculosis MDR strain
25 μM
MIC
PMID25154927 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25154927/
RECORD: Rec_0352851 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-negative
P. falciparum C10
2.13 ± 0.14 μM
EC50
PMID22869378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22869378/
RECORD: Rec_0382455 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium tuberculosis MDR strain GB2
12.5 μM
IC50
PMID25154927 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25154927/
FIRST PREV 1 ... 3 4 5
Showing 4 records on this page · Page 5 of 5