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MYP_132177
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Basic Information
NC-783
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C117H222N34O23S
Standard
Sequence
KRRGGGKLLKLLLKLLLKLLKC
Physicochemical Analysis
2505.29 Da
11.27
7.74
7.52
0.3520
0.31
0.70
-0.08
23.03
177.27
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
954.34
-2.84
36.0
32.0
96.0
175.0
0.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0280994 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-RSV Fusion inhibition
Respiratory syncytial virus (RSV) | MA-104 cell
15.97 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperLinear and dendrimeric antiviral peptides: design, chemical synthesis and activity against human respiratory syncytial virus. | Kozhikhova KV, Shilovskiy IP, Shatilov AA, Timofeeva AV, Turetskiy EA, Vishniakova LI, Nikolskii AA, Barvinskaya ED, Karthikeyan S, Smirnov VV, Kudlay DA, Andreev SM, Khaitov MR | J Mater Chem B. 2020 Apr 1;8(13):2607-2617 | DOI:10.1039/c9tb02485a | PMID:32124885 PMID32124885 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32124885/
RECORD: Rec_0354442 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID32124885 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32124885/
RECORD: Rec_0365958 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
MA-104 cells:CC50= 0
PMID32124885 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32124885/
RECORD: Rec_0421665 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Respiratory syncytial virus (RSV):inhibition of viral infection in the MA-104 cell
40 μg/mL
IC50
PMID32124885 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32124885/