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MYP_132104
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Basic Information
IIQ
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
37 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
IEEIQKKIEEIQKKIEEIQKKIEEIQKKIEEIQKKXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160717 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 inhibition of cell-cell fusion in TZM-bl cells
3.63±0.54 μM
EC50
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0182238 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of pseudovirus infection in Huh-7 cells
0.13±0.1 μM
IC50
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0193884 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid).
Bio-Activity Profile
Antiviral Anti-EBOV Fusion inhibition
Ebola virus (EboV) | TZM-bl cells
1.02±0.54 μM
EC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperDe Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. | Wang C, Zhao L, Xia S, Zhang T, Cao R, Liang G, Li Y, Meng G, Wang W, Shi W, Zhong W, Jiang S, Liu K. | J Med Chem. 2018 Oct 11;61(19):8734-8745. | DOI:10.1021/acs.jmedchem.8b00890 | PMID:30192544 PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0255176 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral
A/Puerto Rico/8/34 (H1N1):inhibition of virus infection in MDCK cells
1.73±0.81 μM
EC50
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0257521 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid).
Bio-Activity Profile
Antiviral Anti-H1N1 Fusion inhibition
A/Puerto Rico/8/34 (H1N1) | MDCK cells
1.73±0.81 μM
EC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperDe Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. | Wang C, Zhao L, Xia S, Zhang T, Cao R, Liang G, Li Y, Meng G, Wang W, Shi W, Zhong W, Jiang S, Liu K. | J Med Chem. 2018 Oct 11;61(19):8734-8745. | DOI:10.1021/acs.jmedchem.8b00890 | PMID:30192544 PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
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