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MYP_132104
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Basic Information
IIQ
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
37 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
IEEIQKKIEEIQKKIEEIQKKIEEIQKKIEEIQKKXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011625 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV:inhibition of cell-cell fusion between 293T / MERS / EGPF cells and Huh-7 cells
0.11±0.02 μM
EC50
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0021490 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
TZM-bl cell
100 μM
CC50
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0050456 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral
Ebola virus (EboV):inhibition of pseudovirus infection in TZM-bl cells
1.02±0.54 μM
EC50
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0111074 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0138806 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
MDCK cell
100 μM
CC50
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
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