Peptide Database

Peptide NameSLAY-screened peptide P4863

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC110H164N34O29

DescriptionStandard

        TINARASGFTNNTRYWIRWV
    

Molecular Weight2426.69 Da

Isoelectric Point (pI)11.71

Net Charge (pH 7.0)2.40

Net Charge (pH 7.4) 2.21

Charge Density (pH 7.0) 0.1199

GRAVY Index-0.54

Hydrophobic Moment 0.64

Boman Index-0.08

Instability Index13.18

Aliphatic Index 63.50

Aromaticity 0.2000

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1063.92

LogP -10.78

H-bond Donors 40.0

H-bond Acceptors 32.0

Rotatable Bonds 74.0

Heavy Atoms 173.0

Ring Count 6.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0304825 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/