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MYP_132100
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Basic Information
Siamycin I
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV
Standard
21 amino acids
C96H135N23O27S4
Standard
Sequence
CLGVGSCNDFAGCGYAVVCFW
Physicochemical Analysis
2171.50 Da
4.05
-1.28
-1.54
-0.0609
1.14
0.28
0.49
33.82
69.52
0.1905
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
781.96
-7.11
31.0
30.0
63.0
150.0
5.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0105567 VERIFIED: YES
Provenance & Taxonomy
Streptomyces strain AA6532 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-positive
Staphylococcus aureus FDA209P JC-1
3.1 μg/mL
MIC
PMID8557614 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8557614/
RECORD: Rec_0137249 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0161325 VERIFIED: YES
Provenance & Taxonomy
Streptomyces strain [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
13-7
Bio-Activity Profile
Antiviral Anti-HIV Antimicrobial
PaperPubMed PMID: 8557614 PMID8557614 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8557614/
RECORD: Rec_0171540 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 33.3%, E 19.0%, T 33.3%, C 14.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiviral Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0207454 VERIFIED: YES
Provenance & Taxonomy
Streptomyces strain AA6532 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-positive
Salmonella typhi 901
100 μg/mL
MIC
PMID8557614 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8557614/
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