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MYP_132054
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Basic Information
Lassomycin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GLRRLFADQLVGRRNICXCHX
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003349 VERIFIED: YES
Provenance & Taxonomy
Actinomycetales sp. [Bacterium]
Nonribosomal peptide
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Cyclization
Methyl ester
Formation of an amide bond between N-terminal amine and the side chain carboxyl group of Asp8.
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis resistant to INH, RIF, STR, EMB, PZA, FQ (188)
1.65 μM
MIC
PMID24684906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24684906/
RECORD: Rec_0025691 VERIFIED: YES
Provenance & Taxonomy
Actinomycetales sp. [Bacterium]
Nonribosomal peptide
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Cyclization
Methyl ester
Formation of an amide bond between N-terminal amine and the side chain carboxyl group of Asp8.
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis resistant to INH, STR (84)
0.83 μM
MIC
PMID24684906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24684906/
RECORD: Rec_0037719 VERIFIED: YES
Provenance & Taxonomy
Actinomycetales sp. [Bacterium]
Nonribosomal peptide
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Cyclization
Methyl ester
Formation of an amide bond between N-terminal amine and the side chain carboxyl group of Asp8.
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis resistant to INH, RIF, STR (86)
0.83 μM
MIC
PMID24684906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24684906/
RECORD: Rec_0038533 VERIFIED: YES
Provenance & Taxonomy
Actinomycetales sp. [Bacterium]
Nonribosomal peptide
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Cyclization
Methyl ester
Formation of an amide bond between N-terminal amine and the side chain carboxyl group of Asp8.
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis resistant to INH, RIF (7)
0.83 μM
MIC
PMID24684906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24684906/
RECORD: Rec_0055154 VERIFIED: YES
Provenance & Taxonomy
Actinomycetales sp. [Bacterium]
Nonribosomal peptide
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Cyclization
Methyl ester
Formation of an amide bond between N-terminal amine and the side chain carboxyl group of Asp8.
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis susceptible 186 clinical isolate
0.83 μM
MIC
PMID24684906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24684906/
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