Peptide Database

Peptide NameVpr-1

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC37H60N8O9

DescriptionStandard

        LQQLLF
    

Molecular Weight760.92 Da

Isoelectric Point (pI)5.53

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0400

GRAVY Index1.20

Hydrophobic Moment 0.41

Boman Index0.45

Instability Index94.77

Aliphatic Index 195.00

Aromaticity 0.1667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 295.00

LogP -0.27

H-bond Donors 9.0

H-bond Acceptors 9.0

Rotatable Bonds 25.0

Heavy Atoms 54.0

Ring Count 1.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0317841 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1:Inhibition of 3′-end processing catalyzed by integrase

Activity11 μM

MethodIC50

RECORD: Rec_0422360 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Replication inhibition

Targetinhibition of strand transfer catalyzed by integrase

Activity68±1 μM

MethodIC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperPeptide HIV-1 integrase inhibitors from HIV-1 gene products. | Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H. | J Med Chem. 2010 Jul 22;53(14):5356-60. | DOI:10.1021/jm1003528 | PMID:20586421 PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/

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