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MYP_132010
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Basic Information
Vpr-1
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
6 amino acids
C37H60N8O9
Standard
Sequence
LQQLLF
Physicochemical Analysis
760.92 Da
5.53
-0.24
-0.44
-0.0400
1.20
0.41
0.45
94.77
195.00
0.1667
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
295.00
-0.27
9.0
9.0
25.0
54.0
1.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0033460 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0038991 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0084131 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
68±1 μM
IC50
PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0211952 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
MT-4
0.068 μM
IC50
PaperPeptide HIV-1 integrase inhibitors from HIV-1 gene products. PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0259036 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
11 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPeptide HIV-1 integrase inhibitors from HIV-1 gene products. | Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H. | J Med Chem. 2010 Jul 22;53(14):5356-60. | DOI:10.1021/jm1003528 | PMID:20586421 PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
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